Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection
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چکیده
منابع مشابه
Genetic Diversity Block 2 of Surface Protein-1 in Plasmodium Falciparum Merozoite by Nested-PCR Method in Southeastern Iran
Abstract Background and Objectives: Plasmodium falciparum merozoite surface protein-1 (PfMSP-1) is a promising vaccine against malaria during its blood stages which play an important role in immunity to this disease. Polymorphic nature of this gene is a major obstacle in making an effective vaccine against malaria. In this study, the genetic diversity of Plasmodi...
متن کاملplasmodium falciparum merozoite surface protein-1 polymorphisms among asymptomatic sickle cell anemia patients in nigeria
asymptomatic malaria (asm) has been implicated in the development of hemolytic crisis in infected sickle cell anemia (sca) patients worldwide. this study surveyed steady state sca nigerian patients for asm to investigate the influence of malaria prevention behaviors and age on parasitaemia and multiplicity of infection (moi). a total of 78 steady sca patients aged 5 – 27 years on routine care a...
متن کاملFine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia.
Antibodies to the C terminus of the Plasmodium falciparum merozoite surface protein, PfMSP-1(19), may inhibit merozoite invasion or block the effects of inhibitory antibodies. Here, using a competition enzyme-linked immunosorbent assay and antibody binding to wild-type and mutated recombinant proteins, we show that there are marked variations between individuals in the fine specificity of natur...
متن کاملPlasmodium falciparum Merozoite Surface Protein-1 Polymorphisms among Asymptomatic Sickle Cell Anemia Patients in Nigeria.
Asymptomatic malaria (ASM) has been implicated in the development of hemolytic crisis in infected sickle cell anemia (SCA) patients worldwide. This study surveyed steady state SCA Nigerian patients for ASM to investigate the influence of malaria prevention behaviors and age on parasitaemia and multiplicity of infection (MOI). A total of 78 steady SCA patients aged 5 - 27 years on routine care a...
متن کاملAnalysis of antibodies directed against merozoite surface protein 1 of the human malaria parasite Plasmodium falciparum.
The 190-kDa merozoite surface protein 1 (MSP-1) of Plasmodium falciparum, an essential component in the parasite's life cycle, is a primary candidate for a malaria vaccine. Rabbit antibodies elicited by the heterologously produced MSP-1 processing products p83, p30, p38, and p42, derived from strain 3D7, were analyzed for the potential to inhibit in vitro erythrocyte invasion by the parasite an...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2010
ISSN: 1475-2875
DOI: 10.1186/1475-2875-9-287